This work brings up a question of using of information technologies for the natural-science museums. Information technology can effectively solve many of the problems traditionally facing museums, including – the main mission of the museum is to store, study and exhibit the museum collection in its entirety. In the case of natural-science museums, information technologies become even more important than for other museums, since collections of a natural-science direction carry a colossal amount of information about natural objects. The article examines the experience of the State Geological Museum and suggests solutions using modern technologies – distributed databases, geoinformation systems, ontological knowledge bases.